Unexplained loss of muscle mass, also known as cachexia, is a complex metabolic disorder characterized by involuntary weight loss, muscle wasting, fatigue, weakness, and a significant loss of appetite. Cachexia differs from starvation, age-related loss of muscle mass, or simple wasting away in that it involves a number of complicating host factors that contribute to severe wasting.
Some potential causes of cachexia include:
- Chronic or severe illness, such as cancer, congestive heart failure, COPD, rheumatoid arthritis, HIV/AIDS, kidney failure or liver disease. The presence of a chronic disease can drive metabolic changes that cause the body to break down muscle.
- Inflammation. High levels of inflammatory markers like cytokines are commonly seen in cachexia. The inflammation induces an increase in muscle breakdown and a decrease in muscle synthesis.
- Hormone imbalance. Abnormal levels of hormones and neurochemicals can lead to cachexia. For example, higher levels of cortisol can accelerate muscle wasting.
- Poor nutrition. Cachexia can worsen in someone whose caloric and protein intake is chronically inadequate. This exacerbates the catabolic state.
Diagnosis is made based on symptoms, labs showing high inflammatory markers, low muscle mass on imaging, and ruling out other causes.
Treatment focuses on addressing any underlying disease, providing
nutritional support,
exercise, and medications that may help counter muscle wasting. For some patients,
hormone replacement with testosterone or anabolic steroids may be beneficial.
At
Hormone Wellness Clinic Health Clinic, our physicians are experts in evaluating unexplained muscle wasting and cachexia. We provide comprehensive
lab testing to assess hormone levels, inflammation, and markers of muscle breakdown. Based on the causes we uncover, we create tailored
treatment plans that may include customized
nutrition advice,
pharmaceutical-grade supplements,
prescription medications as needed, and
follow-up care to help our patients regain strength and muscle mass. Don't wait - if you are experiencing
unexplained muscle loss, schedule a consultation today to start getting answers and solutions from the hormone health experts. We are here to help you regain your vitality!